Masahiro Kobayashi Selected Research

Lamivudine (Epivir)

5/2017	Efficacy of long-term tenofovir-based rescue therapy in patients with chronic hepatitis B refractory to nucleoside/nucleotide analogs.
6/2014	Long-term efficacy and emergence of multidrug resistance in patients with lamivudine-refractory chronic hepatitis B treated by combination therapy with adefovir plus lamivudine.
3/2014	Renal dysfunction and hypophosphatemia during long-term lamivudine plus adefovir dipivoxil therapy in patients with chronic hepatitis B.
5/2010	Efficacy of switching to entecavir monotherapy in Japanese lamivudine-pretreated patients.
4/2010	Clinical and virological effects of long-term (over 5 years) lamivudine therapy.
2/2010	Development of HCC in patients receiving adefovir dipivoxil for lamivudine-resistant hepatitis B virus mutants.
2/2010	Correlation of YMDD mutation and breakthrough hepatitis with hepatitis B virus DNA and serum ALT during lamivudine treatment.
3/2009	Efficacy of entecavir treatment for lamivudine-resistant hepatitis B over 3 years: histological improvement or entecavir resistance?
6/2008	Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up.
1/2008	Changes in viral loads of lamivudine-resistant mutants during entecavir therapy.

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Masahiro Kobayashi Research Topics

Disease

94	Hepatocellular Carcinoma (Hepatoma) 04/2022 - 01/2002
54	Infections 01/2021 - 01/2002
49	Chronic Hepatitis C 12/2020 - 01/2002
48	Chronic Hepatitis B 02/2022 - 01/2002
44	Fibrosis (Cirrhosis) 01/2022 - 01/2002
35	Neoplasms (Cancer) 04/2022 - 01/2002
30	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 01/2002
26	Hepatitis 01/2014 - 01/2002
19	Liver Diseases (Liver Disease) 01/2022 - 01/2002
17	Chronic Hepatitis (Chronic Active Hepatitis) 03/2014 - 01/2003
15	Non-alcoholic Fatty Liver Disease 01/2022 - 01/2011
15	Hepatitis B 01/2022 - 01/2002
11	Carcinogenesis 01/2014 - 01/2003
10	Type 2 Diabetes Mellitus (MODY) 01/2022 - 03/2009
10	Hepatitis C 03/2016 - 09/2005
8	Liver Neoplasms (Liver Cancer) 04/2022 - 12/2010
8	Diabetes Mellitus 01/2022 - 11/2008
8	Anemia 10/2014 - 07/2004
6	Body Weight (Weight, Body) 01/2021 - 10/2007
5	Disease Progression 01/2021 - 01/2004
5	Lymphoma (Lymphomas) 12/2019 - 04/2003
5	Viremia 01/2017 - 01/2007
4	Inflammation (Inflammations) 04/2022 - 01/2003
4	Virus Diseases (Viral Diseases) 04/2021 - 01/2004
4	Neoplasm Metastasis (Metastasis) 10/2018 - 04/2002
4	Hypertension (High Blood Pressure) 03/2014 - 09/2009
3	Fatty Liver 04/2022 - 09/2009
3	Insulin Resistance 01/2022 - 06/2009
3	Wounds and Injuries (Trauma) 01/2021 - 07/2004
3	Hepatic Encephalopathy 12/2019 - 10/2004
3	Thrombocytopenia (Thrombopenia) 10/2017 - 05/2009
3	Persistent Infection 10/2013 - 05/2005
3	Liver Failure 09/2012 - 01/2004
2	Pulmonary Tuberculosis 08/2022 - 05/2020

Drug/Important Bio-Agent (IBA)

66	InterferonsIBA 12/2020 - 01/2002
34	Lamivudine (Epivir)FDA Link 05/2017 - 01/2002
32	Ribavirin (Virazole)FDA LinkGeneric 01/2018 - 01/2002
27	Antiviral Agents (Antivirals)IBA 01/2021 - 01/2004
27	RNA (Ribonucleic Acid)IBA 01/2019 - 01/2003
24	DNA (Deoxyribonucleic Acid)IBA 04/2022 - 02/2002
23	Hepatitis B e AntigensIBA 03/2014 - 01/2002
16	lenvatinibIBA 04/2022 - 11/2018
16	Hepatitis B Surface Antigens (HBsAg)FDA Link 01/2022 - 01/2002
15	Alanine Transaminase (SGPT)IBA 03/2016 - 01/2003
11	entecavir FDA Link 01/2022 - 06/2007
10	AntigensIBA 01/2022 - 01/2002
9	alpha-Fetoproteins (alpha-Fetoprotein)IBA 02/2020 - 01/2003
9	Amino Acids FDA Link 09/2015 - 08/2008
8	BilirubinIBA 10/2017 - 01/2003
7	miriplatinIBA 06/2017 - 01/2011
7	Transaminases (Aminotransferases)IBA 03/2012 - 08/2004
6	Biomarkers (Surrogate Marker)IBA 04/2022 - 12/2007
6	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2022 - 08/2008
6	AlbuminsIBA 01/2019 - 01/2009
6	Serum AlbuminIBA 10/2017 - 10/2007
6	telaprevirIBA 10/2014 - 01/2010
6	adefovir dipivoxil (Hepsera)FDA Link 06/2014 - 01/2004
6	Interferon-alpha (Interferon Alfa)IBA 05/2014 - 02/2002
6	Interferon-betaIBA 01/2011 - 01/2008
5	Fetal Proteins (Fetoprotein)IBA 04/2021 - 09/2013
5	lipoarabinomannan (LAM)IBA 05/2017 - 06/2008
5	asunaprevirIBA 01/2017 - 05/2014
5	daclatasvirIBA 01/2017 - 05/2014
5	adefovirIBA 06/2014 - 01/2004
5	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 01/2011 - 01/2006
4	NucleotidesIBA 02/2022 - 09/2004
4	Sodium-Glucose Transport ProteinsIBA 01/2022 - 01/2017
4	Pharmaceutical PreparationsIBA 01/2022 - 02/2006
4	Sorafenib (BAY 43-9006)FDA Link 02/2021 - 06/2019
4	CreatinineIBA 08/2017 - 03/2013
4	Protease Inhibitors (Protease Inhibitor)IBA 01/2017 - 01/2010
4	Dihydrotachysterol (AT 10)IBA 01/2014 - 03/2009
4	Aspartic Acid (Aspartate)FDA Link 04/2010 - 05/2004
4	Proteins (Proteins, Gene)FDA Link 01/2010 - 03/2006
3	Cell-Free Nucleic AcidsIBA 04/2022 - 02/2020
3	Biological ProductsIBA 01/2022 - 02/2009
3	Surface Antigens (Surface Antigen)IBA 01/2022 - 12/2002
3	CanagliflozinIBA 01/2022 - 05/2019
3	TransferasesIBA 04/2021 - 08/2004
3	Tenofovir (Viread)FDA Link 04/2021 - 01/2014
3	Glucose (Dextrose)FDA LinkGeneric 02/2020 - 06/2012
3	SofosbuvirIBA 01/2018 - 01/2017
3	NucleosidesIBA 05/2017 - 06/2007
3	PlatinumIBA 03/2013 - 04/2009
3	Methionine (L-Methionine)FDA Link 04/2010 - 05/2004
3	Tyrosine (L-Tyrosine)FDA Link 04/2010 - 05/2004
2	Tumor Biomarkers (Tumor Markers)IBA 04/2022 - 01/2008
2	tenofovir alafenamideIBA 02/2022 - 11/2021
2	ZincIBA 01/2022 - 01/2013
2	Blood Proteins (Serum Proteins)IBA 01/2022 - 01/2021
2	Ferritins (Ferritin)IBA 01/2022 - 11/2018
2	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2022 - 08/2020

Therapy/Procedure

137	Therapeutics 08/2022 - 01/2002
17	Radiofrequency Ablation 02/2019 - 01/2002
8	Drug Therapy (Chemotherapy) 01/2021 - 02/2006
6	Aftercare (After-Treatment) 01/2022 - 12/2006
5	Retreatment 03/2019 - 04/2003
5	Drug Tapering 10/2013 - 07/2004
3	Hepatectomy 10/2020 - 11/2017
3	Electrodes (Electrode) 02/2019 - 01/2016